Dr. Jon E. Sprague

Wyeth RP, Mills EM, Ullman A, Kenaston MA, Burwell J, Sprague JE. The hyperthermia mediated by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is sensitive to sex differences. Toxicol. Appl. Pharmacol. In press.

Sprague JE, Sullivan DL, Kane MD. Personalized Medicine: Pharmacogenetics as a method for improving patient outcomes. Ohio Pharmacists. 57(11):13-19, 2008.

Kane MD, Springer JA, Sprague JE. Drug safety assurance through clinical genotyping: near-term
Considerations for a system-wide implementation of personalized medicine. Personalized Med. 5(4): 1-11, 2008.

Banks ML, Czoty PW, Sprague JE, Nader MA. Influence of thyroid hormones on 3,4-methylenedioxymethamphetamine-induced thermogenesis and reinforcing strength in monkeys. Behavioural Pharmacol. 19(2):167-70, 2008.

Banks ML, Sprague JE, Czoty PW, Nader MA. Effects of ambient temperature on the relative reinforcing strength of MDMA using a choice procedure in monkeys. Psychopharmacol (Berl). 196(1): 63-70, 2008.

Banks ML, Sprague JE, Kisor DF, Czoty PW, Nichols DE, Nader MA. Ambient temperature effects on 3,4-methylenedioxymethamphetamine (MDMA)-induced thermodysregulation and pharmacokinetics in male monkeys. Drug Metab Dispos. 35(10): 1840-1845, 2008.

Mills EM, Weaver KL, Abramson E, Pfeiffer M, Sprague JE. Influences of dietary fats on ecstasy-induced hyperthermia. Br. J. Pharmacol. 151(7):1103-1108, 2007.

Sprague JE, Yang X, Sommers J, Gilman TL, Mills EM. Roles of norepinephrine, free Fatty acids, thyroid status, and skeletal muscle uncoupling protein 3 expression in sympathomimetic-induced thermogenesis. J Pharmacol Exp Ther. 320(1):274-280; 2007.

Banks ML, Czoty PW, Sprague JE, Nader MA. Influence of ambient temperature on a primate model of MDMA (Ecstasy) abuse. In: Di Chiara G, Carbon E, Valentini V, Aquas E, Bassareo V, Cadoni C, eds, "Monitoring Molecules in Neuroscience: Proceeding of the 11th International Conference on In Vivo Methods". University of Cagliari, Cagliari, Italy, 2006, pp. 398-400.

Peterson AL, Gilman TL, Banks ML, Sprague JE. Hypothyroidism alters striatal dopamine release mediated by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). Synapse. 59(5):317-319; 2006.

Rusyniak DE, and Sprague JE. Toxin-induced hyperthermic syndromes. Med. Clin. N. Am. 89(6):1277-1296, 2005. (invited review).

Sprague JE, Moze P, Caden D, Rusyniak DE, Holmes C, Goldstein DS, Mills EM. Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylene¬dioxy¬meth¬amphetamine (MDMA, Ecstasy) in an animal model. Crit Care Med. Jun;33(6):1311-6, 2005.

Sprague JE, Nichols DE. Neurotoxicity of MDMA (ecstasy): beyond metabolism. Trends Pharmacol Sci 26(2):59-60, 2005.

Rusyniak DE, Tandy SL, Hekmatyar SN, Mills E, Smith DJ, Bansal N, Maclellan D, Harper ME, Sprague JE. The role of mitochondrial uncoupling in 3,4-methylenedioxymethamphetamine mediated skeletal muscle hyperthermia and rhabdomyolysis. J Pharmacol Exp Ther. 313(2):629-39; 2005.

Mills, E. Rusyniak, D.E. and Sprague, J.E. The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine. J. Mol. Med. 82(12):787-99, 2004 (invited review).

Sprague, J.E., Mallet, N.M., Rusyniak, D.E., and Mills, E. UCP3 and thyroid hormone involvement in methamphetamine-induced hyperthermia. Biochem. Pharmacol. 68(7):1339-1343, 2004.

Hrometz, S.L., Brown, A.W., Nichols, D.E., and Sprague, J.E. 3,4-methylenedioxymethamphetamine (MDMA,ecstasy)-mediated production of hydrogen peroxide in an in vitro model: the role of dopamine, the serotonin-reuptake transporter, and monoamine oxidase-B. Neurosci Lett. 367(1):56-59, 2004

Sprague, J.E., Brutcher, R.E., Mills, E. M., Caden, D., and Rusyniak, D.E. Attenuation of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) induced rhabdomyolysis with ?1- plus ?3-adrenoreceptor antagonists. Br. J. Pharmacol. 142(4):667-670, 2004.

Rusyniak, D.E., Banks, M.L., Mills, E. M., and Sprague, J.E. Dantrolene use in MDMA (Ecstasy) mediated hyperthermia. Anesthesiology. 101(1):263-264, 2004.

Rusyniak, D.E., Scruggs, S.L., Kamendulis, L.M., Sprague, J.E., and Klaunig, J.E. The effects of ecstasy (MDMA) on rat liver bioenergetics. Acad. Emer. Med. 11(7):723-729, 2004.

Mills, E.M., Banks, M.L., Sprague, J.E., and Finkel, T. Uncoupling the agony from
ecstasy. Nature. 426:403-404, 2003.

Sprague, J.E., Banks, M.L., Cook, V.J., and Mills, E. Hypothalamic-Pituitary-Thyroid axis and sympathetic nervous system involvement in the hyperthermia induced by 3,4-methylene¬dioxy¬meth-amphetamine (MDMA, Ecstasy). J. Pharmacol. Exp. Ther. 305(1):159-166, 2003.

Sprague, J.E., Preston, A.S., Leifheit, M., and Woodside, B. Hippocampal Serotonergic Damage induced by MDMA (Ecstasy): Effects on Spatial Learning. Physiol. Behav. 79:281-287, 2003.

Kane, M.D., Lin, H-S, Dombkowski, A.A., Diakiw, A., Nagel, A.C., Flexon, A., Leifheit, M., Sprague, J.E. and Hollenberg, P.F. Accelerating Preclinical Drug Development Using A Microarray-Based Method for Detecting Oxidative Enzyme (P450) mRNA Induction and Other Metabolic Genes in the Rat. In: Hardiman, G., editor. Microarray Methods and Applications: Nuts & Bolts. DNA Press, 2003; pp. 231-248.

Kanthasamy, A., Sprague, J.E., Shotwell, J.R., and Nichols, D.E. Unilateral infusion of a dopamine transporter antisense into the substantia nigra protects against MDMA-induced serotonergic deficits in the ipsilateral striatum. Neuroscience. 114(4):917-924; 2002.

Waites, N.S., and Sprague, J.E. Pharmacology and Toxicology of Ecstasy. U.S. Pharmacist. June 2002.

Falk, E.M., Cook, V., Nichols, D.E and Sprague, J.E. Antisense targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA. Pharmacol. Biochem. Behav. 72:617-622; 2002.

Sprague, J.E., Leifheit, M., Selken, J., Milks, M.M., Kinder, D.H., and Nichols, D.E. In vivo Microdialysis and Conditioned Place Preference Studies in Rats are Consistent with Abuse Potential of Tramadol. Synapse. 43:118-121, 2002.

Elick, K., and Sprague, J.E. Renal and muscle damage induced by the statins. Pharmacy Times. 67(9):22-25, 2001.

Sprague, J.E. Teaching Cardiac Arrhythmias: A focus on pathophysiology and pharmacology. Amer. J. Pharm. Educ. 65:169-177, 2001.

Sprague, J.E.; Worst, T.J.; Haynes, K.; Mosler, C.R.; Nichols, D.E.; Kane, M.D. The pharmacodynamic characterization of an antisense oligonucleotide against monoamine oxidase-B (MAO-B) in rat brain striatal tissue. Cellular Molecular Neuro Bio. 21(1):53-64, 2001.

Jutte, S.B. and Sprague, J.E. An overview of the physiological and pathological roles of the renin- angiotensin system: a focus on the pharmacological regulation. J. Pharmacy Technology. 16:138- 146, 2000.

Sprague, J.E.; Christoff, J.; Allison, J.; Kisor, D.; Sullivan, D. Development and Implementation of an Integrated Cardiovasicular Module in a Pharm.D. Curriculum. Amer. J. Pharm. Edu. 64(1): 20-26, 2000.

Allison, J.C.; Parteleno, P.A.; Streetman, D.S. Hypertension. In: Cardiology for the Non-Traditional Pharm. D. Editor: J.E. Sprague. Council of Ohio Colleges of Pharmacy. Columbus, OH. 1998.

Sprague, J.E.; Harrod, A.D.; Teconchuk, A.L. The pharmacology and abuse potential of ephedrine. Pharmacy Times. 64(5):72-80, 1998.

Sprague, J.E.; Everman, S.L.; Nichols, D.E. An Intregrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine. Neurotoxicol. 19(3):427-442, 1998.

Sprague, J.E. Teaching the pharmacology of angiotensin converting enzyme inhibitors for the treatment of hypertension. Amer. J. Pharm. Edu. 61:173-178, 1997.

Culbertson, J.L.; Sprague, J.E. Obsession with weight loss: an overview of anorexic agents through the years and into the future. Pharmacy Times. 63(6):65-77, 1997.

Faulkner, T.P.; Sprague, J.E. Application of several multimedia approaches to the teaching of CNS pharmacology: Parkinson's disease and antiParkinson's drugs. Amer. J. Pharm. Edu. 60(4):417-421, 1996.

Sprague, J.E.; Johnson, M.P.; Schmidt, C.J.; Nichols, D.E. Studies on the mechanism of p-chloroamphetamine neurotoxicity. Biochem. Pharmacol. 52(8):1271-1277; 1996.

Maickel, R.P.; Sprague, J.E. Role of ACTH fragments in alcohol consumption. In: Stress, Gender, and alcohol-seeking Behavior. Editors: W.A. Hunt & S. Zakhari. NIH Publications, 1995.

Marona-Lewicka, D.; Rhee, G.S.; Sprague, J.E.; Nichols, D.E. Psychostimulant-like effects of para-fluoroamphetamine. Eur. J. Pharmacol. 287:105-113; 1995.

Marona-Lewicka, D.; Rhee, G.S.; Sprague, J.E.; Nichols, D.E. Reinforcing effects of certain serotonin-releasing amphetamine derivatives. Pharmacol. Biochem. Behav. 53(1):99-105; 1996.

Sprague, J.E.; Nichols, D.E. The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylene¬dioxy¬meth¬amphet¬amine-induced lipid peroxidation and long term serotonergic deficits. J. Pharmacol. Exp. Ther. 273(3):667-673;1995.

Sprague, J.E.; Nichols, D.E. Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum. Psychopharmacol. 118:357-359;1995.

Sprague, J.E.; Huang, X.; Kanthasamy, A.; Nichols, D.E. Attenuation of 3,4-methyl¬enedioxy¬-
meth¬amphet¬amine (MDMA)-induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan. Life Sci. 55(15):1193-1198;1994.

Sprague, J.E.; Sharp, D.; Maickel, R.P. Cholinergic regulation of ethanol consumption in rats. Res. Commun. Chem. Pathol. Pharmacol. 15(1&2):1-8;1994.

Sprague, J.E.; Maickel, R.P. Effects of stress and Ebratide (Hoe-427) on free-choice ethanol consumption: comparison of Lewis and Sprague-Dawley rats. Life Sci. 55(11):873-878;1994.

Zabik, J.E.; Sprague, J.E.; Binkerd, K. Central and peripheral components of the inhibitory actions of 5HTP on ethanol consumption in the rat. Pharmacol. Biochem. Behav. 47(3):547-551;1994.

Sprague, J.E.; Fitzgerald, A.L.; Suckow, M.A.; Grigdesby, C.F.; Uetrecht, R.L.; Maickel, R.P. Pharmacological studies of centrifugation-induced analgesia. Pharmacol. Biochem. Behav. 46:911-915;1993.

Zabik, J. E.; Sprague, J.E.; Odio, M. Interactive dopaminergic and noradrenergic systems in the regulation of thirst in the rat. Physiol. Behav. 54(1):29-33;1993.

ABSTRACTS:

Rusyniak, D.E., Scrugg, S.L., and Sprague, J.E. Ecstasy's effects on in-vitro and ex-vivo oxidative phophorylation in rodent skeletal muscle. SAEM abstract 99; 2004.

Woodside, B.L., Preston, A.S., Leifheit, M.C., and Sprague, J.E. Hippocampal serotonergic damage induced by ecstasy (MDMA): effects on spatial learning. Soc. Neurosci. Abstracts. 2003.

Sprague, J.E., Banks, M.L., Mills, E.M., and Rusyniak, D.E. 3,4-methylene¬dioxy¬meth¬amphetamine (MDMA, Ecstasy) induced changes in striatal temperature and uncoupling protein (UCP) expression. Soc. Neurosci. Abstracts. 638.3, 2003.

Brown, A.W., Hrometz, S.L., and Sprague, J.E. The Role of Dopamine Deamination as the Source of Free-Radicals Responsible for MDMA-Mediated Serotonergic Neurotoxicity using an

In Vitro Model. Pfizer Summer Undergraduate Research Fellowship recipient poster presentation. Groton, CT, October, 2003.

Preston, A.S.; and Sprague, J.E. The role of excessive MAO-B activity in the learning deficits induced by ageing and ecstasy. American Geriatrics Society Abstracts. 69, 2003.

Sprague, J.E.; Banks, M.L.; and Mills, E.M. UCP3 involvement in the peripheral hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). Soc. Neurosci. Abstracts. 469.5, 2002.

Leifheit, M., Preston, A., and Sprague, J.E. Effects of aging on MAO-B mediated serotonergic neurotoxicity induced by 3,4-methylenedioxymethamphetamine. Pfizer Fellowship Seminar. 2002.

Falk, E.M., Cook, V.J., and Sprague, J.E. Antisense targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA. AACP Abstracts. 2002.

Cook, V.J.; Woodley, N.; Sprague, J.E. Effects of antisense knockdown of monoamine oxidase-B on acute dopamine release induced by 3,4-methylenedioxymethamphetamine. Ohio J. Sci. 102(1):A-9, 2002. and Beta Beta Beta District Convention, April 2002.

Banks, M.L., Hall, C.R., Kane, M.D., and Sprague, J.E. Antisense regulation of mdr1a and mrp1 gene expression in the blood brain barrier: effects on CNS drug concentrations. Pfizer Fellowship Seminar. 2002.

Cook, V., Falk, E.M., and Sprague, J.E. Antisense targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA. Bioinformatics Symposium for Drug Development. 2001.

Leifheit, M., Aouad, J., Christoff, J., and Sprague, J.E. The role of dopamine autooxidation in the selective serotonergic neurotoxicity induced by 3,4-methylene¬dioxy¬meth¬amphetamine (MDMA). Annual West Virginia Undergraduate Research Seminar. Paper 4, 2001 and Beta Beta Beta District Convention, April 2002.

Hall, C., and Sprague, J.E. ICV Administered Antisense Regulation of Multi-Drug Resistant (mdr1a) P-Glycoproteins and Multi-Drug Resistance Associated Proteins (mrp) in the Rat Brain: Implications for Microdialysis Pharmacokinetic Characterization of CNS Active Compounds. AACP Abstracts. 2001.

Sprague, J., Kanthasamy, A., and Nichols, D.E. Use of antisense technologies to study the role of Dopamine in MDMA neurotoxicity. NIDA Ecstasy Program. 53; 2001.

Faulkner, T.P.; Sprague, J.E.; Kier, K.; Bryant, B.G. Development and implementation of a modular-based, entry-level, doctor of pharmacy program. AACP Abstracts. 2000.

Sprague, J.E.; Worst, T.J.; Kanthasamy, A.; Nichols, D.E.; Kane, M.D. Antisense reduction of MAO-B activity and mRNA expression in rat brain fails to protect against MDMA-induced serotonergic neurotoxicity: relevance to neuroprotection mechanisms. Soc. Neurosci. Abstracts. 25(2):836.19;1999.

Haynes K, Worst TJ, Kane MD, Sprague JE. The pharmacodynamic characterization of an antisense oligonucleotide against MAO-B in the rat brain. Pfizer Fellowship Seminar. 1999.

Worst TJ, Kane MD, Sprague JE. Effects of altered MAO-B gene expression with antisense oligonucleotide on MDMA-induced serotonergic neurotoxicity. Pfizer Fellowship Seminar. 1998.

Haynes K, Dagani MA, Sprague JE. Effect of catalase inhibition on MDMA (Ecstasy) induced serotonergic neurotoxicity. ONU Sigma Xi Undergraduate Poster Session. 1998.

Harrod, A.; Mosler, C.R.; Sprague, J.E. Potentiation of warfarin's anticoagulant effects with clarithromycin. 19th Annual West Virginia Undergraduate Research Seminar. Paper 39, 1997.

Antrim, A.L.; Harrod, A.; Sprague, J.E. Effects of MDMA (Ecstasy) on chronic ethanol consumption. Sigma Xi ONU Undergraduate Research Poster Session. 1997 and the 19th Annual West Virginia Undergraduate Research Seminar. Paper 38, 1997.

Mosler, C.R.,; Culbertson, J.L.; Sprague, J.E. Serotonergic neurotoxicity of ethanol and p-chloroamphetamine: effects on chronic alcohol consumption. 19th Annual West Virginia Undergraduate Research Seminar. Paper 31, 1997.

Culbertson, J.L.; Sprague, J.E. Investigations into the interneuronal connections involved in the development of ethanol-induced serotonergic neurotoxicity and alcohol consumption. AACP Abstracts. 1997.

Teconchuk, A.; Yount, M.; Sprague, J.E. Effects of neurotoxic doses of ethanol on the development of chronic ethanol consumption. Sigma Xi ONU Undergraduate Research Poster Session. 1997.

Antrim, A.L.; Harrod, A.; Sprague, J.E. Effects of MDMA (Ecstasy) on chronic ethanol consumption. Sigma Xi ONU Undergraduate Research Poster Session. 1997.

Culbertson, J.L.; Sprague, J.E. Ethanol-induced serotonergic neurotoxicity: a possible link to chronic ethanol consumption. 18th Annual West Virginia Undergraduate Research Seminar. 18:1; 1996.

Faulkner, T.P.; Sprague, J.E. Application of several multimedia approaches to the teaching CNS pharmacology: Parkinson's disease and antiParkinson's drugs. AACP Abstracts. Page 147, 1996.

Sprague, J.E.; Wasti, S.T.; Nichols, D.E. Differential effects of MAOIs on [3H]paroxetine binding in the striatum, hippocampus, and frontal cortex following treatment with MDMA and PCA. Soc. Neurosci. Abstracts. 21(1):99.13;1995.

Marona-Lewicka, D.; Sprague, J.E.; Nichols, D.E. Conditioned place preference effects of the 5-methoxy-2-amino indan (MMAI): a comparison study with entactogens and fenfluramine. Soc. Neurosci. Abstracts. 20 (1):379;1994.

Sprague, J.E.; Maickel, R.P. Structure-activity relationships for peptide fragments of ACTH[1-39] and free-choice consumption of ethanol by rats. Sigma XI. 3:48;1994.

Sprague, J.E.; Sharp, D.; Maickel, R.P. Free-choice ethanol consumption by adrenalectomized rats: possible receptor down-regulation. Pharmacologist. 35(3):132;1993.

Sprague, J.E.; Zabik, J. E. Preliminary study of the application of microdialysis in lead neurotoxicity: correlation of behavior and dopamine release. Current Separations. 12(2):41;1993.

Sprague, J.E.; Suckow, M.A.; Uetrecht, R.C.; Maickel, R.P. Pharmacological studies of analgesia induced by centrifugal swinging (cs) of rats. FASEB. 7(3): A485;1993.

PUBLICATION AND BOOK REVIEWS:

Sprague, J.E. Charting the future while preserving tradition. The Ohio Society of Health-System Pharmacists Bulletin. 27(5):7, 2007.

Sprague, J.E. Ecstasy: Playing a game of chemical Russian roulette. ONU Alumni J. Spring: 20-21, 2002

Mosler, C.R., and Sprague, J.E. Raves and Club Drugs. ONU Continue Education Series. http://webct.onu.edu/SCRIPT/clubdrugsCE/scripts/serve_home

Wilhelm, J.M., and Sprague, J.E. A review of bleeding disorders and the pharmacologic rational for desmopressin in their therapy. ONU Pharmacy Continuing Education Series. http://webct.onu.edu/SCRIPT/desmopressinCE/scripts/serve_home

Sprague, J.E. Book Review: Pharmacology: Drug Actions and Reactions. Amer. J. Pharm. Edu. 64(4):474-475, 2001.

Sprague, J.E. Book Review: Pharmacology. Amer. J. Pharm.Edu. 64, 2000.

Sprague, J.E. Book Review: Pharmacology. Amer. J. Pharm.Edu. 62(2):237-238, 1998.

Sprague, J.E. Book Review: Essentials of Pharmacology. Amer. J. Pharm. Edu. 60:106, 1996.
PUBLICATION AND BOOK REVIEWS CONTINUED:
Sprague, J.E. Book Review: Annual Review in Pharmacology and Toxicology. Amer. J. Pharm. Edu. 60(4):434, 1996.

Sprague, J.E., Oberlander, R.A.; Dettloff, R.W.; Hushka, D.R.; Greenlee, W.F.; Nichols, D.E. The entry level Pharm.D. degree---truly "doctoral?" AACP News. 26(6): 2-3; 1995.

CONTINUING EDUCATION & PROFESSIONAL PRESENTATIONS:

"Cardiac Arrhythmia: pathophysiology & pharmacology." Ohio Pharmacist Asssociation meeting 4/07.

"Club Drugs." American Society of Addictive Medicine 1/07.

"Neurobiology of Opioid Addiction." ETSU CME Program 7/05.

"Pharmacological management of hyperlipidemia." Ohio Pharmacist Association meeting 4/05.

"Drug therapy of hypertension based on pharmacologic mechanisms." Ohio Pharmacist Association meeting 4/04.

"Drug therapy of heart failure based on pharmacologic mechanisms. Ohio Pharmacist Association meeting 11/03.

"The CYP P450 System: Implications for drug-interactions with Statins." Findlay Physicians. 10/03.

Pharmacologic regulation of the Autonomic Nervous System. Ohio Pharmacist Association meeting and ONU. 4/03 and 1/05.

The Journal Television Show, WBGU PBS. "Ecstasy." 11/01.

WLIO Noon Edition. "Club Drugs: The Danger of Ecstasy." 12/01.

"Drugs of Abuse and Patient Care." Council of Ohio Colleges of Pharmacy. Eduucircuit. 11/01.

"The Book of Life." Ohio Northern Pharmacy-Law Symposium. 7/01.

"How's your heart? Cardiac Risk Factors. ONU Alumni College Seminars. 6/01.

Reality Check Television Show. "Club Drugs." 2/01.

"Prevention and Treatment of Myocardial Infarction." Council of Ohio Colleges of Pharmacy. Eduucircuit. 11/00.

"Diabetes Management." Council of Ohio Colleges of Pharmacy. Educircuit. 4/00.

"Development and implementation of an integrated cardiovascular module." AACP Chemistry Section Meeting, AACP National Meeting. 7/99.

"The Neuropharmacology of Drug Abuse: A focus on Ecstasy and LSD." Ohio Northern Pharmacy-Law Symposium. 7/97.

"Interviewing: when to start, where to go, how to prepare, what to do." AACP Graduate Student Forum: Preparing for your first faculty position. AACP National Meeting. 7/97.

"Dyslipidemia and the pharmacological rational for the treatment." Merck Dyslipidemia Pharmacist Training Series. 6/97.

"Ma Huang: From Chinese Legend to American Nightmare." Ohio Northern Pharmacy-Law Symposium. 7/96, West Central Society of Hospital Pharmacist 11/96, Ohio Northern College of Law Ethics and Substance Abuse Symposium 11/96.

SCIENTIFIC PRESENTATIONS:

42nd Annual Bergy Lecture: Uncoupling the Agony from the Ecstasy. West Virginia University 3/06.

Distinguished Pharmacology Lecture: MDMA-induced hyperthermia. International Physiology Meeting. 3/06

"Uncoupling the agony from ecstasy." Butler University 2/04, NEOUCOM 4/04, Wake Forest Univesity 11/06.

"Role of dopamine deamination and hyperthermia in the serotonergic neurotoxicity induced by MDMA." Heidelberg 1/03, Indiana-Purdue University Medical Center 3/03, Eli-Lilly 4/03, West Virginia University 6/03.

"Role of dopamine deamination in the serotonergic neurotoxicity induced by MDMA." Beta Beta Beta District Convention, Ohio Northern University 4/02.

"Role of dopamine deamination in the serotonergic neurotoxicity induced by MDMA." Purdue University 10/01.

"Abuse potential of tramadol." Ohio State DUR Board Meeting 5/01.

"Effects of altered MAO-B gene expression with antisense oligonucleotides on MDMA-induced serotonergic neurotoxicity." Parke Davis 12/98.

"Substituted amphetamine and ethanol induced serotonergic neurotoxicity: effects on chronic alcohol consumption." Ohio Northern University, Sigma Xi Meeting 1/98.

"Investigations into the mechanisms by which 3,4-methylenendioxymethamphetamine (MDMA)-induces selective serotonergic neurotoxicity." Western University 4/97.

"Investigations into the mechanisms by which 3,4-methylenendioxymethamphetamine (MDMA)-induces selective serotonergic neurotoxicity." Michigan State University 4/97.

MANUSCRIPT REVIEW (ad hoc):

American Journal of Pharmaceutical Education
American Journal of Physiology
Biochemical Pharmacology
BMC Neuroscience
Brain Research
Brain Research Bulletin
British Journal of Pharmacology
Japanese Journal of Pharmacology
Journal of Neurochemistry
Journal of Neuropsychiatry and Clinical Neuroscience
Journal of Pharmacology and Experimental Therapeutics
Neuropharmacology
Neuropsychopharmacology
Neurotoxicology & Teratology
Pharmacology, Biochemistry andBehavior
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Psychopharmacology
Psychiatric Services

PROFESSIONAL SERVICES:

Community
Pastor Nominating Committee Bluffton Presbyterian Church
Institutional Review Board Lima Memorial and St. Rita's Hospital
Elder Bluffton Presbyterian Church (1997-2000)
University:
Institutional Animal Care and Use Committee, Chair (1998-2004)
Student Affairs Committee, Chair (1998-1999)
Radiation Safety Officer (1996-1998)
College:
Curriculum Committee, Chair
Research Committee, Chair
Cardiovascular Module Committee, Chair
Faculty Affairs Committee (1998-2001)
Grant Review:
Science Foundation Ireland (2004)
Medical Research Council of South Africa (2002-2003)
AACP/Merck (2002-2003)
NIH Member, NMB and NAL Special Emphasis Panel Study Sections (SRA - Michael Selmanoff, 2004)
NIH Study Section: Biobehavioral and Behavioral Processes Integrated Review Group, 2006

FUNDING:

National Institutes of Health (R15). $247,500 total project. Uncoupling the agony from Ecstasy. Funded through 2010.

Edward Via Virginia College of Osteopathic Medicine IRC Grant. $31,622 total project. Alpha1 adrenergic responses are gender sensitive in the hyperthermia and hypertension induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). Funded through 2006.

American Foundation for Pharmaceutical Education Gateway Undergraduate Research Grant. $5,000 total project. Hypothalamic Noradrenergic Regulation of 3,4-methylene¬dioxy¬meth-amphetamine (MDMA, Ecstasy) -mediated hyperthermia. Funded through 2004.

Bowyer, J. Bennett, H. Bennett Chair of Pharmacy Research Grant. $10, 000 total project. The role of CYP2D6 inhibition in the hyperthermia induced by 3,4-methylene¬dioxy¬meth¬amphet¬amine (MDMA, Ecstasy)

National Institutes of Health (R15). $101,250 total project. Ecstasy's neurotoxicity: role of hyperthermia. Funded through 2008.

Bowyer, J. Bennett, H. Bennett Chair of Pharmacy Research Grant. $12, 500 total project. Ecstasy-induced neurotoxicity: role of dopamine deamination.

Pfizer Undergraduate Summer Research Fellowship. $5,000 total project. In-vitro and in-vivo studies into the role of dopamine in the neurotoxicity induced by Ecstasy. Funded through August 2003.

ONU Summer Undergraduate Research Initative Grant. $5,333 total project. Hypothalamic-Pituitary-Thyroid axis and Uncoupling Protein-3 (UCP3) involvement in the hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). Funded through August 2002.

Faculty Development Grant, Ohio Northern University. $1,500 total project. The role of excessive MAO-B activity in the learning deficits induced by Aging and Ecstasy. Funded through August 2002.

American Foundation for Pharmaceutical Education Gateway Undergraduate Research Grant. $5,000 total project. The role of excessive dopamine metabolism by MAO-B in the serotonergic neurotoxicity induced by 3,4- methylene¬dioxymethamphetamine (MDMA, Ecstasy). Funded through June 2003.

American Federation for Aging Research Grant. $4,000 total project. The role of excessive MAO-B activity in the learning deficits induced by Aging and Ecstasy. Funded through August 2002.

Pfizer Undergraduate Summer Research Fellowship. $5,000 total project. Role of aging on MAO-B mediated serotonergic neurotoxicity induced by 3,4-methylenedioxymethamphetamine (MDMA). Funded through August 2002.

American Society of Pharmacology and Experimental Therapeutics (ASPET). $2,500 total project. Effects of ambient temperature on 3,4-methylenedioxymethamphetamine-induced hyperthermia, acute dopamine release and long-term serotonergic neurotoxicity. Funded through August 2002.

Faculty Development Grant, Ohio Northern University. $1,500 total project. Role of monoamine oxidase-B in the serotonergic neurotoxicity induced by MDMA. Funded through August 2001.

American Foundation for Pharmaceutical Education Gateway Undergraduate Research Grant.
$5,000 total project. The role of dopamine autooxidation in the selective serotonergic neurotoxicity induced by MDMA. Funded through June 2002.

Merck undergraduate research fellowship grant. Summer Project. $5,500 total project. Funded
through June 2002.

Pfizer Undergraduate Summer Research Fellowship. $5,000 total project. Antisense regulation of mdr1a and mrp1 gene expression in the blood-brain barrier: Effects on CNS drug concentrations. Funded through August 2001.

Genomic Solutions. Gene Expression and Enzyme Induction. $6,000 total project.

Merck undergraduate research fellowship grant. Summer Project. $5,500 total project. Funded through June 2001.

Faculty Development Grant, Ohio Northern University. $1,500 total project. Antisense regulation of multi-drug resistant protein (mdr1a) P-glycoprotein and multi-drug resistance associated protein (mrp) in the rat brain. Funded through August 2000.

Pfizer Undergraduate Summer Research Fellowship. $5,000 total project. Characterization of the pharmacodynamic effects of an antisense sequence against MAO-B. Funded through August 2000.

Faculty Development Grant, Ohio Northern University. $1,500 total project. The pharmacodynamic characterization of an antisense oligonucleotide against MAO-B in the rat brain. Funded through August 1999.

Pfizer Undergraduate Summer Research Fellowship. $5,000 total project. The pharmacodynamic characterization of an antisense oligonucleotide against MAO-B in the rat brain. Funded through August 1999.

Faculty Development Grant, Ohio Northern University. $1,500 total project. The role of dopamine in the development of ethanol-induced serotonergic neurotoxicity. Funded through August 1998.

Improvement of Teaching Grant, Ohio Northern University. $1,500 total project. Development of a computer assisted technology program for the pharmacy NAPLEX exam: an implementation and assessment study. Funded through May 1998.

FUNDING CONTINUED:
Pfizer Undergraduate Summer Research Fellowship. $5,000 total project. Effects of altered MAO-B gene expression with antisense oligonucleotides on MDMA-induced serotonergic neurotoxicity. Funded through August 1998.

Improvement of Teaching Grant, Ohio Northern University. $3,900 total project. Development of a computer-adapted technology program for self-assessment and integrated therapeutic module implementation. Funded through August 1998.

Faculty Development Grant, Ohio Northern University. $800 total project. Investigations into the role ethanol-induced serotonergic neurotoxicity. Funded through August 1997.

Merck undergraduate research fellowship grant. Summer Project. $7,000 total project. Funded through June 1997.

Faculty Development Grant, Ohio Northern University. $1,300 total project. Investigations into the role of selective serotonergic neurotoxicity in the development of alcoholism. Funded through August 1996.

Faculty Development Grant, Ohio Northern University. $500 total project. Potential neurotoxic interaction of the anorectic agents, fenfluramine and phentermine. Funded through December 1995.