Dr. Janelle Crossgrove
Submitted by c-dunbar on Fri, 01/02/2009 - 11:01pm.
Assistant Professor of Toxicology
Pharmaceutical and Biomedical Sciences
525 S. Main Street
Ada, OH 45810
j-crossgrove@onu.edu
419-772-3954
Accumulation of beta-amyloid peptides in brain extracellular fluid is thought to be the crucial step in the onset of Alzheimer's disease (AD). Our published studies reveal that the choroid plexus (CP), a major component of the blood-cerebrospinal fluid (CSF) barrier, removes bet-amyloid peptides from CSF. We hypothesize that the reason more females than males develop AD is due to hormonal differences in the ability of the CP to remove the toxic beta-amyloid peptides. In addition to exploring the relationship between sex and beta-amyloid transport at the CP, our work provides the foundation to study (1) how environmental and inflammatory models of AD may have altered beta-amyloid clearance or uptake by the CP; (2) how known CP toxicants with little or no identified AD association may affect beta-amyloid homeostasis; (3) how aging may alter normal beta-amyloid clearance; and (4) whether certain genetic changes or pharmacological agents may prevent detrimental changes in the barrier's protective function.
Current Course Curriculum
PHBS 210 Pharmaceutical Science Techniques
PHBS 443 Biomedical Sciences 1
PHBS 444 Biomedical Sciences 2
BSPC 441 BSPC Module 1: The Cardiovascular System
BSPC 444 BSPC Module 4: The Endocrine and Musculoskeletal System
BSPC 445 BSPC Module 5: Oncology and Gastrointestinal System
Professional Experience:
- Society of Toxicology
- Ohio Valley Regional Chapter of the Society of Toxicology
- Elected as Councilor in 2009-2010
- American Association of Colleges of Pharmacy
- Selected to receive a New Investigator's Program award
- American Society for Pharmacology and Experimental Therapeutics
Education:
- B.A. Hiram College
- Ph.D. University of Kentucky
Research Interests:
CNS & Metals toxicology, Brain barriers and neurodegenerative disease.
Selected Publications:
J. S. Crossgrove, E. L. Smith, and W. Zheng. (2007). Macromolecules involved in production and metabolism of beta-amyloid at the brain barriers. Brain Research, 1138, 187-195.
J. S. Crossgrove, G. J. Li and W. Zheng. The choroid plexus removes beta-amyloid from the cerebrospinal fluid. Experimental Biology and Medicine, 2005, 230(10):771-776. (Best Paper of the Year 2005 for the Society of Experimental Biology and Medicine.)
J. S. Crossgrove and R. A. Yokel. Manganese distribution across the blood-brain barrier IV. Evidence for brain influx through store-operated calcium channels. NeuroToxicology, 2005, 26(3):297-307.
J. S. Crossgrove and R. A. Yokel. Manganese distribution across the blood-brain barrier III. The divalent metal transporter-1 is not essential for brain manganese uptake. NeuroToxicology, 2004, 25(3):451-460.
J. S. Crossgrove, G. J. Li and W. Zheng. The choroid plexus removes beta-amyloid from the cerebrospinal fluid. Experimental Biology and Medicine, 2005, 230(10):771-776. (Best Paper of the Year 2005 for the Society of Experimental Biology and Medicine.)
J. S. Crossgrove and R. A. Yokel. Manganese distribution across the blood-brain barrier IV. Evidence for brain influx through store-operated calcium channels. NeuroToxicology, 2005, 26(3):297-307.
J. S. Crossgrove and R. A. Yokel. Manganese distribution across the blood-brain barrier III. The divalent metal transporter-1 is not essential for brain manganese uptake. NeuroToxicology, 2004, 25(3):451-460.